The synthesis of water soluble dendrimers, and their application as possible drug delivery systems

LJ Twyman, AE Beezer, R Esfand, MJ Hardy…

Index: Twyman, Lance J.; Beezer, Anthony E.; Esfand; Hardy, Martin J.; Mitchell, John C. Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1743 - 1746

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Citation Number: 239

Abstract

The synthesis of two water soluble dendrimers is described. The formation of water soluble inclusion complexes with a variety of small, hydrophobic guest molecules is also described. Moreover, when these guest molecules are drug moieties, then the resulting drug/dendrimer complexes can be considered ideal candidates for use as novel drug delivery systems.