SOME N-MONO-AND N, N'-DISUBSTITUTED DERIVATIVES OF 2-PIPERAZINECARBONITRILE

…, C DRĂGHICI, C Florea, M Maganu

Index: Petride, Horia; Draghici, Constantin; Florea, Cristina; Maganu, Maria Revue Roumaine de Chimie, 2008 , vol. 53, # 7 p. 515 - 526

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Abstract

Five new 4-R1-mono-and 1-R1-4-R2-disubstituted derivatives (R1, R2= benzyl, benzoyl) of 2-piperazinecarbonitrile were synthesized and fully characterized by PMR and CMR spectral methods. By comparison with model compounds, a preferred axial position was advanced for the cyano group. Substitution of the aminic hydrogen atom by a benzyl or benzoyl group affected the NMR chemical shifts of all piperazine atoms. Careful spectral ...