Synthesis of citrate–ciprofloxacin conjugates

…, GH Thomas, AK Duhme-Klair, A Routledge

Index: Md-Saleh, Siti R; Chilvers, Emily C.; Kerr, Kevin G.; Milner, Stephen J.; Snelling, Anna M.; Weber, Jan P.; Thomas, Gavin H.; Duhme-Klair, Anne-Kathrin; Routledge, Anne Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1496 - 1498

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Citation Number: 19

Abstract

Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.