Microwave-assisted solvent-free synthesis of the substituted spiroindolinonaphth [2, 1-b][1, 4] oxazines

…, R Guglielmetti, J Hamelin, F Texier-Boullet…

Index: Koshkin; Fedorova; Lokshin; Guglielmetti; Hamelin; Texier-Boullet; Gromov Synthetic Communications, 2004 , vol. 34, # 2 p. 315 - 322

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Citation Number: 11

Abstract

Abstract The synthesis of the substituted spiroindolinonaphth [2, 1-b][1, 4] oxazines 3a–e is developed through the condensation of 2-methylene-1, 3, 3-trimethylindoline derivatives and 1-nitroso-2-naphthol under microwave irradiation. In the same conditions, in presence of morpholine the 6′-morpholinosubstituted compounds 4a, b, d, e are formed. The main advantages of the method are the short reaction time, solvent-free reaction condition, ...