Novel, potent THC/anandamide (hybrid) analogs

…, JL Wiley, BR Martin, BF Thomas, A Mahadevan…

Index: Bourne, Caryl; Roy, Sucharita; Wiley, Jenny L.; Martin, Billy R.; Thomas, Brian F.; Mahadevan, Anu; Razdan, Raj K. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7850 - 7864

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Citation Number: 11

Abstract

The structure–activity relationship (SAR) of the end pentyl chain in anandamide (AEA) has been established to be very similar to that of Δ9-tetrahydrocannabinol (Δ9-THC). In order to broaden our understanding of the structural similarities between AEA and THC, hybrid structures 1–3 were designed. In these hybrids the aromatic ring of THC–DMH was linked to the AEA moiety through an ether linkage with the oxygen of the phenol of THC. Hybrid 1 ( ...