Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [ …

P Madsen, A Ling, M Plewe, CK Sams…

Index: Journal of Medicinal Chemistry, , vol. 45, # 26 p. 5755 - 5775

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Citation Number: 78

Abstract

... Journal of Medicinal ... 5775. DOI: 10.1021/jm0208572. Publication Date (Web): November 20, 2002. Copyright © 2002 American Chemical Society. ... Highly potent human glucagon receptor (hGluR) antagonists have been prepared employing both medicinal chemistry and targeted ...