General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen
A Numata, Y Kondo, T Sakamoto
Index: Numata, Atsushi; Kondo, Yoshinori; Sakamoto, Takao Synthesis, 1999 , # 2 p. 306 - 311
Full Text: HTML
Citation Number: 72
Abstract
Abstract: Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N- oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes. Key words: naphthyridines, N-oxides, cyclization, palladium- catalyzed acetylene cross-coupling, lithiation
Related Articles:
[Phuan, Puay-Wah; Kozlowski, Marisa C Tetrahedron Letters, 2001 , vol. 42, # 24 p. 3963 - 3965]
[Horne, Daniel B.; Tamayo, Nuria A.; Bartberger, Michael D.; Bo, Yunxin; Clarine, Jeffrey; Davis, Carl D.; Gore, Vijay K.; Kaller, Matthew R.; Lehto, Sonya G.; Ma, Vu V.; Nishimura, Nobuko; Nguyen, Thomas T.; Tang, Phi; Wang, Weiya; Youngblood, Beth D.; Zhang, Maosheng; Gavva, Narender R.; Monenschein, Holger; Norman, Mark H. Journal of Medicinal Chemistry, 2014 , vol. 57, # 7 p. 2989 - 3004]
[Horne, Daniel B.; Tamayo, Nuria A.; Bartberger, Michael D.; Bo, Yunxin; Clarine, Jeffrey; Davis, Carl D.; Gore, Vijay K.; Kaller, Matthew R.; Lehto, Sonya G.; Ma, Vu V.; Nishimura, Nobuko; Nguyen, Thomas T.; Tang, Phi; Wang, Weiya; Youngblood, Beth D.; Zhang, Maosheng; Gavva, Narender R.; Monenschein, Holger; Norman, Mark H. Journal of Medicinal Chemistry, 2014 , vol. 57, # 7 p. 2989 - 3004]