Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 2. Condensed heterocyclic derivatives.

…, K Kosaka, Y INoue, T IMADA, C FUKAYA…

Index: Ono, Shin'ichiro; Yoshida, Tomohiro; Maeda, Kazuhiro; Kosaka, Keigo; Inoue, Yoshihisa; Imada, Teruaki; Fukaya, Chikara; Nakamura, Norifumi Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 12 p. 1694 - 1712

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Citation Number: 8

Abstract

A novel series of platelet receptor glycoprotein (Gp) IIb/IIIa antagonists with condensed heterocycles as their basic core was synthesized. In an in vitro assay, trans-4-(5- amidinobanzofuran-2-carboxamido) cyclohexyloxyacetic acid 17e and trans-3-[4-(5- amidinobanzofuran-2-carboxamido) cyclohexyl] propionic acid 17f produced marked inhibitions with IC 50 values of 0.018 and 0.006 μM, respectively in a human platelet ...