Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone

…, V Hernandez, Y Zhou, CZ Ding, J Li, Z Shao…

Index: Li, Xianfeng; Zhang, Yong-Kang; Plattner, Jacob J.; Mao, Weimin; Alley; Xia, Yi; Hernandez, Vincent; Zhou, Yasheen; Ding, Charles Z.; Li, Jinpeng; Shao, Zhijun; Zhang, Hongwei; Xu, Musheng Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 963 - 966

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Citation Number: 6

Abstract

We have designed and synthesized a novel class of compounds based on fluoroquinolone antibacterial prototype. The design concept involved the replacement of the 3-carboxylic acid in ciprofloxacin with an oxaborole-fused ring as an acid-mimicking group. The synthetic method employed in this work provides a good example of incorporating boron atom in complex molecules with multiple functional groups. The antibacterial activity of the newly ...