Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic-and anxiolytic-like effects in mice

…, NG Echemendia, LC Williams, T De Paulis…

Index: Galici, Ruggero; Jones, Carrie K.; Hemstapat, Kamondanai; Nong, Yi; Echemendia, Nicholas G.; Williams, Lilly C.; De Paulis, Tomas; Conn, P. Jeffrey Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 318, # 1 p. 173 - 185

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Citation Number: 137

Abstract

Abstract Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide a novel approach for the treatment of anxiety disorders and schizophrenia. However, the relative contributions of the mGluR2 and mGluR3 subtypes to the effects of the group II mGluR agonists remain unclear. In the present study, we describe an alternate synthesis and further pharmacological ...