2-Methyl-1, 3-dioxaazaspiro [4.5] decanes as novel muscarinic cholinergic agonists

J Saunders, GA Showell, RJ Snow…

Index: Saunders, John; Showell, Graham A.; Snow, Roger J; Baker, Raymond; Harley, Elizabeth A.; Freedman, Stephen B. Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 486 - 491

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Citation Number: 26

Abstract

Many nonquaternary ammonium muscarinic agonists have been developed over the last few years, but most of the existing compounds (eg, arecoline, RS-86, AF-30) behave as weak partial agonists at cholinergic receptors in tissues of limited receptor reserve. The current paper describes the synthesis and biochemical assessment of analogues of AF-30 designed to have sufficient conformational freedom to allow greater receptor flexibility and ...