Inhibition of monoamine oxidase B by selective adenosine A 2A receptor antagonists
…, JF Chen, MA Schwarzschild, CJ Van der Schyf…
Index: Petzer, Jacobus P.; Steyn, Salome; Castagnoli, Kay P.; Chen, Jiang-Fan; Schwarzschild, Michael A.; Van Der Schyf, Cornelis J.; Castagnoli, Neal Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1299 - 1310
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Citation Number: 103
Abstract
Adenosine receptor antagonists that are selective for the A2A receptor subtype (A2A antagonists) are under investigation as possible therapeutic agents for the symptomatic treatment of the motor deficits associated with Parkinson's disease (PD). Results of recent studies in the MPTP mouse model of PD suggest that A2A antagonists may possess neuroprotective properties. Since monoamine oxidase B (MAO-B) inhibitors also enhance ...
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