Tetrahedron

Synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis

K Fuhshuku, Y Asano

Index: Fuhshuku, Ken-Ichi; Asano, Yasuhisa Tetrahedron, 2012 , vol. 68, # 33 p. 6651 - 6655

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Citation Number: 6

Abstract

The synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis is described. The amidation of optically active N-Boc-allylglycine derivatives with N- protected alkenylamine, and ring-closing metathesis resulted in the formation of medium- sized α-aminolactams with good yield.