Convenient method for synthesis of N-protected α-amino epoxides: key intermediates for HIV protease inhibitors

…, M Roy, S Hariharan, C Headley, A Upare…

Index: Blacker, A. John; Roy, Mita; Hariharan, Sivaramkrishanan; Headley, Catherine; Upare, Abhay; Jagtap, Ashutosh; Wankhede, Karuna; Mishra, Sushil Kumar; Dube, Dagadu; Bhise, Sanjay; Vishwasrao, Sandesh; Kadam, Nitin Organic Process Research and Development, 2011 , vol. 15, # 2 p. 331 - 338

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Citation Number: 13

Abstract

A convenient method for synthesis of 2 R, 3 S and 2 S, 3 SN-Boc phenylalanine epoxides using readily available allylamine is described. Previous methods employed multistep synthetic routes from l-phenyl alanine that include use of m-chloroperbenzoic acid (m- ...