Studies on several 7-substituted N, N-dimethyltryptamines

…, E Schubert, JM Jacyno, JA Rosecrans

Index: Glennon, R. A.; Schubert, E.; Jacyno, J. M.; Rosecrans, J. A. Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1222 - 1226

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Citation Number: 22

Abstract

Several 7-substituted derivatives of Nfl-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me-and 50Me-7-Me-DMT possess a higher pA2, and 5, 7- (OMeI2-DMT a lower pAz, than that of DMT itself. Like DMT, all three of these compounds produce behavioral effects in rata which are similar to those of the hallucinogen 5-OMe- ...