Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development …

L Zehnder, M Bennett, J Meng, B Huang…

Index: Journal of Medicinal Chemistry, , vol. 54, # 9 p. 3368 - 3385

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Citation Number: 23

Abstract

... Journal of Medicinal Chemistry. ... In this report, we describe our medicinal chemistry efforts that afforded a novel class of Hsp90 inhibitors that exhibit potent efficacy in animal tumor models along with other desirable pharmaceutical properties. figure ...