Pyridazinemonocarboxylic acids and derivatives

WJ Leanza, HJ Becker, EF Rogers

Index: Leanza et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4086

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Citation Number: 36

Abstract

In connection with recent studies of nitrogen heterocyclic amides' and hydrazides, new syntheses of pyridazine-3-carboxylic acid and pyridazine-4-carboxylic acid were developed. Gabriel and Colman2 first made pyridazine-3-carboxylic acid by the permanganate oxidation of 3-9-hydroxyphenylpyridazine. In the present work two alternate routes to the 3- acid were explored. Permanganate oxidation of 3-hydroxymethylpyridazine and reductive ...