Reduction of pyrimidine derivatives by LiAlH4

…, Z Qi-Qi, W Qing-Min, L Ying, H Run-Qiu

Index: Yu-Xiu, Liu; Ming-Bo, Cui; Qi-Qi, Zhao; Qing-Min, Wang; Ying, Liu; Run-Qiu, Huang Journal of Chemical Research, 2007 , # 8 p. 490 - 493

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Abstract

The reduction of ethyl 2-methylthio-(or 2-ethoxy) pyrimidine-5-carboxylate by LiAlH4 afforded ethyl 2-methylthio-(or 2-ethoxy)-1, 6-dihydropyrimidine-5-carboxylate as the main product. Similarly, the reduction of 2-methylthio-(or 2-methoxy) pyrimidine-5-carboxamide by LiAlH4 gave 2-methylthio-(or 2-methoxy)-1, 6-dihydropyrimidine-5-carbonitrile as main product.