Coupled conformational equilibria in β-sheet peptide-dendron conjugates

H Shao, JW Lockman, JR Parquette

Index: Shao, Hui; Lockman, Jeffrey W.; Parquette, Jon R. Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1884 - 1885

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Citation Number: 29

Abstract

A series of peptide-dendron conjugates, based on an intrinsically α-helical, alanine-rich sequence, were constructed to explore how the conformational equilibria of each structural element can be conformationally coupled. The interdendron spacing was varied from i, i+ 4 (2) to i, i+ 11 (9) to probe how the nature of the dendron interaction impacted the conformational properties. These studies revealed an α-helix to β-sheet conformational ...