Tetrahedron

Haloalkane dehalogenase catalysed desymmetrisation and tandem kinetic resolution for the preparation of chiral haloalcohols

A Westerbeek, JGE van Leeuwen, W Szymański…

Index: Westerbeek, Alja; Van Leeuwen, Jan G.E.; Szymanski, Wiktor; Feringa, Ben L.; Janssen, Dick B. Tetrahedron, 2012 , vol. 68, # 37 p. 7645 - 7650

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Citation Number: 10

Abstract

Six different bacterial haloalkane dehalogenases were recombinantly produced in Escherichia coli, purified, and used to catalyse the conversion of prochiral short-chain dihaloalkanes and a meso dihaloalkane, yielding enantioenriched haloalcohols. A two- reaction one-enzyme process was established in which the desymmetrisation of a dihaloalkane is followed by kinetic resolution of the chiral haloalcohol that is produced in ...