Cyclopropylamines from N, N??Dialkylcarboxamides and Grignard Reagents in the Presence of Titanium Tetraisopropoxide or Methyltitanium Triisopropoxide

…, B Stecker, V Gazizova, AI Savchenko…

Index: De Meijere, Armin; Chaplinski, Vladimir; Winsel, Harald; Kordes, Markus; Stecker, Bjoern; Gazizova, Vesta; Savchenko, Andrei I.; Boese, Roland; Schill, Farina Chemistry - A European Journal, 2010 , vol. 16, # 46 p. 13862 - 13875

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Citation Number: 15

Abstract

Abstract Thirty-three different N, N-dialkyl-and N-alkyl-N-phosphorylalkyl-substituted carboxamides 9–17 were treated with unsubstituted as well as with 2-alkyl-, 2, 2-dialkyl-, and 3-alkenyl-substituted ethylmagnesium bromides 6 in the presence of stoichiometric amounts of titanium tetraisopropoxide or methyltitanium triisopropoxide to furnish substituted cyclopropylamines 20–25 in 20–98% yield, depending on the substituents with no (1: 1) to ...