An improved method for the synthesis of nucleoside triphosphate analogues

S Mohamady, DL Jakeman

Index: Mohamady, Samy; Jakeman, David L. Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10588 - 10591

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Citation Number: 44

Abstract

Nucleoside monophosphates, when activated by trifluoroacetic anhydride and N- methylimidazole, efficiently couple with a variety of electron-deficient diphosphonates in a reproducible and efficient manner (< 2 h,> 72% isolated yield). Unlike traditional methods for the preparation of nucleoside 5'-β, γ-methylenetriphosphate analogues, there is no requirement for predrying, or conversion to specific salt forms, of commercially available ...