Longiberine and O-Methyllongiberine, Dimeric Protoberberine-Benzyl Tetrahydroisoquinoline Alkaloids from Thalictrum l ongistyl um 1

…, JH Wilton, JL Beal, RW Doskotch

Index: Lee, Shoei-Sheng; Wu, Wu-Nan; Wilton, John H.; Beal, Jack L.; Doskotch, Raymond W. Journal of Natural Products, 1999 , vol. 62, # 10 p. 1410 - 1414

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Citation Number: 11

Abstract

Two benzyltetrahydroisoquinoline-protoberberine dimers, longiberine (1) and O- methyllongiberine (2), were isolated from the roots of Thalictrum longistylum and represent a new class of dimeric alkaloids. The structure of longiberine (1) was established by spectral and chemical methods. Reductive cleavage of O-ethyllongiberine (4) with Na/liquid NH3 yielded (+)-(S)-N-methylcoclaurine (5), which determined one-half of the dimer, and 1D ...