Tetrahedron Letters

A short synthesis of (+)-hygrine

EB Arévalo-García, JCQ Colmenares

Index: Arevalo-Garcia, Enzo B.; Colmenares, Juan Carlos Q. Tetrahedron Letters, 2008 , vol. 49, # 25 p. 3995 - 3996

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Citation Number: 13

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis of the alkaloid hygrine in a series of six steps starting from readily available proline N-methyl derivative (5) is described. ... Thus, treatment of the readily available 5 4 with DIBAL-H in CH 2 Cl 2 at −30 °C afforded aldehyde 4. This product, without further purification, was then ...