SYNTHESIS AND CHARACTERIZATION OF NUCLEOSIDE DERIVATIVES, N-(BENZOYL)-N-(DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL AND N-(2′- …

…, KR Ravi Kumar, KS Rangappa

Index: Mallesha; Ravi Kumar; Rangappa Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 4-5 p. 385 - 392

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Citation Number: 2

Abstract

ABSTRACT Lead tetraacetate (LTA) oxidation of α-Phenyl-N-(4-biphenyl) nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N- (deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (11).