Tetrahedron: Asymmetry

Enzyme assisted syntheses of chiral building blocks for isosters of diglycerides, phospholipids and PAF

K Lange, MP Schneider

Index: Lange, Karsten; Schneider, Manfred P. Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2811 - 2815

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Citation Number: 6

Abstract

Lipase catalyzed desymmetrizations of suitably substituted, achiral 1, 3-diols lead to the corresponding chiral building blocks of high enantiomeric purities, starting materials for the synthesis of isosteric carba-analogues of 1, 2-sn-diglycerides and phospholipids with interesting biological activities. Lipase catalyzed resolutions of the corresponding ether derivatives lead to the corresponding building blocks for carba-analogues of PAF.