Thyromimetics. V. The Synthesis and Biological Screening of α-Methylthyroxine

…, EG Rice, FR Pfeiffer, CM Greenberg

Index: Blank; Rice; Pfeiffer; Greenberg Journal of medicinal chemistry, 1966 , vol. 9, # 1 p. 10 - 15

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Citation Number: 2

Abstract

X successfu1. j Current therapy for hyperthyroidism prescribes the use of thiourea-like conipounds to inhibit thyroxine synthesis and/or destruction of thyroidal tissue by radioactive iodine or surgical excisio~ i.~”~ The availability of a chemical agent which could inhibit the peripheral action of the thyroid hormones and/or suppress the synthesis and release of these substances from the thyroid gland would provide an attractive adjuvant to the ...