Direct synthesis of primary arylamines via C–N cross-coupling of aryl bromides and triflates with amides

M Romero, Y Harrak, J Basset, JA Orúe, MD Pujol

Index: Romero; Harrak; Basset; Orue; Pujol Tetrahedron, 2009 , vol. 65, # 10 p. 1951 - 1956

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Citation Number: 19

Abstract

Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100–150° C without solvent, and with low catalyst levels (0.12 mol% Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction.