Chemoselective carbon-carbon coupling of organocuprates with (bromomethyl) methylmaleic anhydride: Synthesis of chaetomellic acid A
AM Deshpande, AA Natu…
Index: Deshpande, Anil M.; Natu, Arvind A.; Argade, Narshinha P. Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9557 - 9558
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Citation Number: 39
Abstract
Chaetomellic anhydrides A and B have been recently isolated1 from Chaetomella acutiseta, and their dianionic forms are potent and highly specific inhibitors of ras farnesyl-protein transferase. The provision of facile synthetic approaches to this bioactive natural product, Chaetomellic acid A anhydride (tetradecylmethylmaleic anhydride, 1e), is a task of current interest. 2-9 Seven alternate syntheses of 1e, including two from our group, 6, 7 have ...
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