Amino group protection in peptide synthesis. 4, 5-Diphenyl-4-oxazolin-2-one group
JC Sheehan, FS Guziec Jr
Index: Sheehan,J.C.; Guziec,F.S. Journal of Organic Chemistry, 1973 , vol. 38, p. 3034 - 3040
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Citation Number: 34
Abstract
The preparation and properties of 4, 5-diphenyl-4-oxazolin-2-one (Ox) derivatives (1) of amino acids are described and these derivatives evaluated as protected intermediates in peptide synthesis. The Ox group-one of the few protecting groups which mask both hydrogens of a primary amino function-is unreactive undei the usual conditions used to remove protecting groups, but may be cleaved under mild reductive or oxidative ...
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