Tetrahedron: Asymmetry

An efficient aldol-based approach for the synthesis of dihydrokawain-5-ol

A Kamal, PV Reddy, S Prabhakar

Index: Kamal, Ahmed; Reddy, Papagari Venkat; Prabhakar Tetrahedron Asymmetry, 2009 , vol. 20, # 16 p. 1936 - 1939

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Citation Number: 7

Abstract

An efficient and simple aldol-based convergent approach toward the total synthesis of (+)- and (−)-dihydrokawain-5-ol is described. The key features of this synthetic strategy include Evans' aldol reaction and an ethyl acetate addition reaction for the formation of the six- membered ring.