Tetrahedron letters

Synthesis of an oxyamino-containing phenanthroline derivative for the efficient preparation of phenanthroline oligonucleotide oxime conjugates

…, E Defrancq, C Moucheron, A Kirsch-De Mesmaeker…

Index: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382

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Citation Number: 25

Abstract

A phenanthroline derivative bearing an oxyamino linker was efficiently prepared from commercial 5-nitro-1, 10-phenanthroline. The subsequent reaction with an oligonucleotide containing an aldehyde either at the 5′ end or the 3′ end afforded, in good yield, the phenanthroline–oligonucleotide conjugates through oxime bond formation.