Tetrahedron

One-step cross-coupling reaction of functionalized alkyl iodides with aryl halides by the use of an electrochemical method

N Kurono, K Sugita, S Takasugi, M Tokuda

Index: Kurono, Nobuhito; Sugita, Kazuya; Takasugi, Shingo; Tokuda, Masao Tetrahedron, 1999 , vol. 55, # 19 p. 6097 - 6108

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Citation Number: 33

Abstract

Organozinc compounds of functionalized alkyl iodide carrying an alkoxycarbonyl, cyano or alkenyl group were prepared in high yields under mild conditions (0° Cr. t., 10min in DMF) by the reaction of iodides with an electrogenerated reactive zinc (EGZn). Cross-coupling of the organozinc compounds with various aryl halides in the presence of 5 mol% Pd (P (o-Tol) 3) 2Cl2 in THF gave the corresponding cross-coupled products in moderate to high yields. ...