Tetrahedron letters

LiBF 4-Catalyzed three-component coupling of an aldehyde, acetic anhydride and allyltrimethylsilane/TMSCN

JS Yadav, BVS Reddy, P Vishnumurthy, CJ Chary

Index: Yadav; Reddy, B.V. Subba; Vishnumurthy; Chary, Ch. Janardhana Tetrahedron Letters, 2007 , vol. 48, # 33 p. 5915 - 5918

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Citation Number: 5

Abstract

Lithium tetrafluoroborate is found to be an efficient catalyst for allylation and cyanation of aldehydes with allyltrimethylsilane and trimethylsilyl cyanide in the presence of acetic anhydride at room temperature to produce homoallylic acetates and α-cyano acetates in excellent yields. A solution of 10mol% of LiBF4 in acetonitrile provides a convenient reaction medium to carry out allylation and cyanation reactions under very mild and neutral ...