Synthesis and Antiinflammatory Activity of Isonicotinic and Cinchoninic Acid Derivatives

…, AI Mikhalev, ME Kon'shin, MV Vasilyuk…

Index: Pavlova; Mikhalev; Kon'shin; Vasilyuk; Kotegov Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 425 - 427

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Abstract

It was reported that amides of isonicotinic [1, 2], 2-chloroisonicotinic [3], 2-chlorocinchoninic [5, 6], and 2-oxocinchoninic [7, 8] acids possess antiinflammatory properties. In continuation of the previous investigations aimed at finding new effective antiinflammatory agents, we have synthesized a series of previously unreported substituted amides and esters of 2- chloroisonicotinic acid (Ia–Ij, Table 1) and aryl esters of 2-chloro-(IIa–IIg) and 2- ...