Enantioselective Synthesis of Functionalized 1??Benzoxepines by Phenoxide Ion Mediated 7??endo??tet Carbocyclization of Cyclic Sulfates

SK Das, SK Dinda, G Panda

Index: Das, Sajal Kumar; Dinda, Subal Kumar; Panda, Gautam European Journal of Organic Chemistry, 2009 , # 2 p. 204 - 207

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Citation Number: 7

Abstract

Abstract A new asymmetric synthesis of 2, 3-disubstituted 1-benzoxepines is described. Key steps include Sharpless asymmetricdihydroxylation of trans-α, β-unsaturated esters and phenoxide ion mediated intramolecular 7-endo-tet carbocyclization of syn-2, 3-dihydroxy ester derived cyclic sulfates.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)