A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose–stimulated chemotaxis of human neutrophils

…, JI Sesma, CB Ball, PS Jayasekara, KA Jacobson…

Index: Barrett, Matthew O.; Sesma, Juliana I.; Ball, Christopher B.; Jayasekara, P. Suresh; Jacobson, Kenneth A.; Lazarowski, Eduardo R.; Harden, T. Kendall Molecular Pharmacology, 2013 , vol. 84, # 1 p. 41 - 49

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Citation Number: 20

Abstract

Abstract The nucleotide-sugar–activated P2Y 14 receptor (P2Y 14-R) is highly expressed in hematopoietic cells. Although the physiologic functions of this receptor remain undefined, it has been strongly implicated recently in immune and inflammatory responses. Lack of availability of receptor-selective high-affinity antagonists has impeded progress in studies of this and most of the eight nucleotide-activated P2Y receptors. A series of molecules ...