Total Synthesis of Pradimicinone, the Common Aglycon of the Pradimicin–Benanomicin Antibiotics

M Kitamura, K Ohmori, T Kawase…

Index: Kitamura, Mitsuru; Ohmori, Ken; Kawase, Toshihisa; Suzuki, Keisuke Angewandte Chemie - International Edition, 1999 , vol. 38, # 9 p. 1229 - 1232

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Citation Number: 79

Abstract

Abstract A benzo [a] naphthacenequinone core, an amino acid, and a disaccharide are the constituents of pradimicin–benanomicin antibiotics 1 (R 1= disaccharide), a class of natural products with significant antifungal and anti-HIV activities. The first total synthesis of pradimicinone (benanomicinone, 1; R 1= H), the common aglycon of this class of natural products, has now been achieved based on the transmission of chirality during the pinacol ...