An Apoptosis??Inducing Small Molecule That Binds to Heat Shock Protein 70

DR Williams, SK Ko, S Park, MR Lee…

Index: Williams, Darren R.; Ko, Sung-Kyun; Park, Sungjin; Lee, Myung-Ryul; Shin, Injae Angewandte Chemie - International Edition, 2008 , vol. 47, # 39 p. 7466 - 7469

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Citation Number: 42

Abstract

Apoptosis (or programmed cell death) is a fundamental biological process that regulates a variety of normal physiological processes, ranging from development to aging.[1] Damaged or unwanted cells in organisms are removed by the intrinsic and/or extrinsic apoptotic pathways. The intrinsic apoptotic pathway occurs by the release of cytochrome c from mitochondria. The extrinsic apoptotic pathway is caused by the binding of death ligands, ...