Tetrahedron: Asymmetry

Almond oxynitrilase-catalyzed transformation of aldehydes is strongly influenced by naphthyl and alkoxy substituents

G Roda, S Riva, B Danieli

Index: Roda, Gabriella; Riva, Sergio; Danieli, Bruno Tetrahedron Asymmetry, 1999 , vol. 10, # 20 p. 3939 - 3949

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Citation Number: 25

Abstract

Different α-and β-substituted aldehydes have been submitted to the catalytic action of almond oxynitrilase (PaHNL), in order to explore the influence of a stereocenter already present in the substrate on the selectivity of this enzyme. The results indicate that naphthyl and alkoxy substituents in the α-and also in the β-position to the aldehyde group significantly influence the stereochemical outcome of the PaHNL-catalyzed transformation.