Bioorganic & medicinal chemistry

Linear propargylic alcohol functionality attached to the indazole-7-carboxamide as a JAK1-specific linear probe group

MK Kim, H Shin, SY Cho, Y Chong

Index: Kim, Mi Kyoung; Shin, Heerim; Cho, Seo Young; Chong, Youhoon Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1156 - 1162

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Citation Number: 5

Abstract

Abstract Selective inhibition of JAK1 has recently been proposed as an appropriate therapeutic rationale for the treatment of inflammatory diseases such as rheumatoid arthritis (RA). In this study, through pairwise comparison and 3D alignment of the JAK isozyme structures bound to the same inhibitor molecule, we reasoned that an alkynol functionality would serve as an isozyme-specific probe group, which would enable the resulting ...

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