Tetrahedron Letters

Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes: an aniline mediated synthesis of 2-substituted quinolines

H Li, C Wang, H Huang, X Xu, Y Li

Index: Li, Hongfeng; Wang, Chengyu; Huang, He; Xu, Xiaolei; Li, Yanzhong Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1108 - 1111

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Citation Number: 31

Abstract

An efficient silver-catalyzed, aniline mediated cascade hydroamination/cycloaddition of o- aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones with alkynes for the synthesis of 2-or 2, 4-substituted quinolines is reported. The reactions proceed with high regioselectivity to afford mono-or disubstituted quinoline derivatives in good to high yields using AgOTf as the catalyst in the air.

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