Iridium-Catalyzed, Substrate-Directed C–H Borylation Reactions of Benzylic Amines

AJ Roering, LVA Hale, PA Squier, MA Ringgold…

Index: Roering, Andrew J.; Hale, Lillian V. A.; Squier, Phillip A.; Ringgold, Marissa A.; Wiederspan, Emily R.; Clark, Timothy B. Organic Letters, 2012 , vol. 14, # 13 p. 3558 - 3561

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Citation Number: 30

Abstract

The iridium-catalyzed arene C–H borylation reaction of benzylic amines has been developed, which inverts the typical steric-controlled product distribution to provide ortho- substituted boronate esters. Picolylamine was found to be an ideal ligand to replace 4, 4′ ...