Journal of Fluorine Chemistry

Preparative-scale synthesis of 3, 3, 3-trifluoropropene oxide

PV Ramachandran, KJ Padiya

Index: Ramachandran, P. Veeraraghavan; Padiya, Kamlesh J. Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1255 - 1259

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Citation Number: 5

Abstract

Bromination of 3, 3, 3-trifluoropropene in 20% oleum, followed by treatment with acetic acid furnishes 2-bromo-3, 3, 3-trifluoropropyl acetate in quantitative yield, which upon acid hydrolysis and cyclization with alkali affords 3, 3, 3-trifluoropropene oxide (TFPO) in 63% overall yield.