Nitrogen analogs of 1, 4-benzoquinones. Activities against the ascitic sarcoma 180 of mice

EM Hodnett, G Prakash…

Index: Hodnett,E.M. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 11 - 16

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Citation Number: 20

Abstract

Compounds having the basic structure N-(R)-substituted ring-substituted 4- iminocyclohexadienone have been synthesized and tested as antitumor agents against the ascitic sarcoma 180 tumor in Swiss mice. Among these compounds, the dimethylindoanilines [R= 4-(CHJ2NCeH4] are most stable in water at pH 7.0 and at 25" C, the oximes (R= OH) are less stable, and the N-halo Compounds (R= Br and C1) are least ...