A simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm
MNS Rad, A Khalafi-Nezhad, S Behrouz, MA Faghihi
Index: Soltani Rad, Mohammad Navid; Khalafi-Nezhad, Ali; Behrouz, Somayeh; Faghihi, Mohammad Ali Tetrahedron Letters, 2007 , vol. 48, # 38 p. 6779 - 6784
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Citation Number: 20
Abstract
A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p- toluenesulfonyl) imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n- butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols ...
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