Model studies toward the synthesis of dihydropyrimidinyl and pyridyl α-amino acids via three-component Biginelli and Hantzsch cyclocondensations

A Dondoni, A Massi, E Minghini…

Index: Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E. Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2385 - 2387

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Citation Number: 126

Abstract

... Volume: Page: ... 14 h; (b) NaH, BnBr, DMF; (c) AcOH−H 2 O (5:1), rt; (d) 1 M Jones reagent, 0 °C to rt, 3 h; (e) H 2 ... Also in this homologous series, direct conversion of 12 into the corresponding amino acids 15 failed due to a competitive oxidation of the DHPM ring ...