Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High??Throughput Screening

M Vasan, J Neres, J Williams, DJ Wilson…

Index: Vasan, Mahalakshmi; Neres, Joao; Williams, Jessica; Wilson, Daniel J.; Teitelbaum, Aaron M.; Remmel, Rory P.; Aldrich, Courtney C. ChemMedChem, 2010 , vol. 5, # 12 p. 2079 - 2087

Full Text: HTML

Citation Number: 24

Abstract

Abstract A simple steady-state kinetic high-throughput assay was developed for the salicylate synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small-molecule iron chelators produced by M. tuberculosis, and their biosynthesis has been identified as a promising target for the development of new antitubercular agents. The assay was ...