Synthesis of 5-substituted 3-isoxazolecarboxylic acid hydrazides and derivatives

TS GARDNER, E Wenis, J LEE

Index: Gardner,T.S. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 1514 - 1518

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Citation Number: 49

Abstract

Some 5-substituted 3-isounzolecartiouylic wid hytlrazidcs have been prepared for investigation of their anti-lepra1 aetivit v The 5-methyl, n-propyl, and isobutyl compounds showed activity. The 5-methyl compound was superior. Other alkyl residues gave less activity. Aromatic or heterocyclic residues conferred no special activity. Some derivatives and related compounds\ rere prepared.