Regioselective radical arylation of anilines with arylhydrazines

…, J Scheumann, MR Heinrich

Index: Jasch, Hannelore; Hoefling, Sarah B.; Heinrich, Markus R. Journal of Organic Chemistry, 2012 , vol. 77, # 3 p. 1520 - 1532

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Citation Number: 40

Abstract

Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivities, and anilines have been shown to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as ...